=====Insulin like growth factor===== The insulin-like growth factors (IGFs) are [[protein]]s with high sequence similarity to [[insulin]]. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (Insulin-like growth factor 1 (IGF-I) and Insulin-like growth factor 2 ([[IGF-2]])), a family of six high-affinity IGF-binding proteins (IGFBP-1 to IGFBP-6), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. see [[IGF-1]]. see [[IGF-2]].