====== Image-Guided Magnetic Thermoseed Navigation ======

Medical therapies achieve their control at the expense of the patient in the form of a range of toxicities, which incur [[cost]]s and diminish the [[quality of life]]. [[Magnetic resonance]] [[navigation]] is an emergent technique that enables image-guided remote-control of magnetically labeled therapies and devices in the body, using a [[magnetic resonance imaging]] (MRI) system. Minimally INvasive IMage-guided Ablation (MINIMA), a novel, minimally invasive, MRI-guided [[ablation]] technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an [[MRI]] scanner, before inducing localized cell death using an MR-compatible thermoablative device. Baker et al. demonstrated precise thermoseed imaging and navigation through [[brain tissue]] using an MRI system (0.3 mm), and they perform [[thermoablation]] [[in vitro]] and [[in vivo]] within [[subcutaneous]] [[tumor]]s, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel [[theranostics]] platform, combining [[imaging]], [[navigation]], and heating to deliver [[diagnosis]] and [[therapy]] in a single device
((Baker RR, Payne C, Yu Y, Mohseni M, Connell JJ, Lin F, Harrison IF, Southern P, Rudrapatna US, Stuckey DJ, Kalber TL, Siow B, Thorne L, Punwani S, Jones DK, Emberton M, Pankhurst QA, Lythgoe MF. [[Image-Guided Magnetic Thermoseed Navigation]] and [[Tumor Ablation]] Using a [[Magnetic Resonance Imaging]] System. Adv Sci (Weinh). 2022 Feb 2:e2105333. doi: 10.1002/advs.202105333. Epub ahead of print. PMID: 35106965.)).