====== IDH-mutant primary glioblastoma ======

IDH-mutant [[primary glioblastoma]]s have better prognosis than [[secondary glioblastoma]]s and have major molecular differences from other commoner [[glioblastoma]]s. G-CIMP subgroups, [[MGMT promoter methylation]], and [[TP53 mutation]] are useful prognostic adjuncts
((Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK. Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas. Mod Pathol. 2021 Mar 10. doi: 10.1038/s41379-021-00778-x. Epub ahead of print. PMID: 33692446.)).