====== ID4 ======


ID4 is a [[protein-coding gene]]. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4.

This [[protein]] is known to be involved in the [[regulation]] of many cellular processes during both [[prenatal]] development and [[tumorigenesis]]. This is inclusive of embryonic cellular growth, [[senescence]], cellular differentiation, [[apoptosis]], and as an [[oncogene]] in [[angiogenesis]].
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Zhang et al. found that [[Id4]] is a [[downstream]] target of [[Notch2]] signaling and maintains [[dentate gyrus]] (DG) [[Neural stem cell]]s (NSCs) [[quiescence]] by blocking cell-cycle entry. Id4 expression is sufficient to promote DG NSC quiescence and Id4 knockdown rescues Notch2-induced inhibition of NSC proliferation. Id4 deletion activates NSC proliferation in the DG without evoking neuron generation, and overexpression increases NSC maintenance while promoting astrogliogenesis at the expense of [[neurogenesis]]. Together, these findings indicate that Id4 is a major effector of Notch2 signaling in NSCs and a Notch2-Id4 axis promotes NSC quiescence in the adult DG, uncoupling NSC activation from neuronal differentiation
((Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D, Taylor V. Id4
Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult
Hippocampus. Cell Rep. 2019 Aug 6;28(6):1485-1498.e6. doi:
10.1016/j.celrep.2019.07.014. PubMed PMID: 31390563.
)).