====== Hypothermia in acute ischemic stroke ======

[[Neuroprotection]] of [[hypothermia]] in [[acute ischemic stroke]] is well documented. However, the mechanisms involved in the effects remain to be clearly elucidated and the role of hypothermia on long-term [[white matter]] integrity after acute [[ischemic stroke]] has yet to be investigated.

Mild focal hypothermia treatment immediately after ischemic stroke significantly promotes WM integrity 28 days after [[middle cerebral artery occlusion]] (MCAO) in [[mice]]. Higher integrity of white matter, lower activation of total [[microglia]], less [[infarct]] volume, and better neurobehavioral function were detected in hypothermia-treated mice compared to normothermia-treated mice. Furthermore, Liu et al. found that hypothermia could decrease detrimental M1 phenotype microglia and promote healthy M2 phenotype microglia. In vitro, results also indicated that hypothermia promoted [[oligodendrocyte]]s differentiation and maturation after oxygen glucose deprivation.

Hypothermia promotes long-term WM integrity and inhibits [[neuroinflammation]] in a mouse model of ischemic brain injury
((Liu LQ, Liu XR, Zhao JY, Yan F, Wang RL, Wen SH, Wang L, Luo YM, Ji XM.
Brain-selective mild hypothermia promotes long-term white matter integrity after 
ischemic stroke in mice. CNS Neurosci Ther. 2018 Sep 16. doi: 10.1111/cns.13061. 
[Epub ahead of print] PubMed PMID: 30295998.
)).