====== High-grade glioma classification ======

^ Grade ^ Tumor Types ^ Key Features ^
| **Grade 3** | - Anaplastic astrocytoma \\ - Anaplastic oligodendroglioma | - High cellularity \\ - Mitotic activity \\ - No necrosis |
| **Grade 4** | - [[Glioblastoma]] (GBM) \\ - Diffuse midline glioma, H3 K27-altered | - Necrosis \\ - Microvascular proliferation \\ - Often IDH-wildtype \\ - Very poor prognosis |



● [[Astrocytoma IDH-mutant Grade 3]] 

● [[Astrocytoma IDH-mutant Grade 4]]


Anaplastic astrocytoma with mutations in the IDH gene.


[[Anaplastic oligodendroglioma, IDH-mutant & 1p/19q-codeleted]]

[[Diffuse midline glioma H3 K27-altered]]

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see also [[Glioma classification]]

The term malignant or [[High-grade glioma]] refers to [[tumor]]s that are classified as:

●[[WHO Grade 3 glioma]]: 

[[Anaplastic astrocytoma]], [[anaplastic oligodendroglioma]], [[anaplastic oligoastrocytoma]], [[anaplastic ependymoma]]



● [[WHO Grade 4 glioma]]
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[[Pediatric High-grade glioma]].

[[Brainstem High-grade glioma]].

[[Cystic High-grade glioma]].

[[Pediatric High-grade glioma]].

[[Recurrent High-grade glioma]].

[[Temporal lobe high-grade glioma]].

[[Thalamic High-grade glioma]].

[[Ventricular High-grade glioma]].