====== High-grade astrocytoma ====== High-grade [[astrocytoma]]s are fast-growing and often spread within the brain and spinal cord. There are several types of high-grade astrocytomas. High-grade astrocytomas can be either: Grade III tumors–[[anaplastic astrocytoma]] or [[anaplastic pleomorphic xanthoastrocytoma]]. ---- Grade IV tumors–[[glioblastoma]] or [[diffuse midline glioma]]. ---- Childhood astrocytomas usually do not spread to other parts of the body.