[[HIF1A]] and [[HIF2A]] are the two main [[molecule]]s that contribute to Glioblastoma malignant progression by inhibiting [[apoptosis]] or maintaining stemness under hypoxic conditions. Moreover, [[Sox2]], a marker of stemness, also contribute to Glioblastoma malignant progression through stemness maintenance of cell cycle arrest. Briefly, HIF1α, HIF2α, and [[Sox2]] are highly expressed under [[hypoxia]] and contribute to Glioblastoma growth and [[chemoresistance]]. However, after exposure to HBO for Glioblastoma, whether the expression of the above factors is decreased, resulting in chemosensitization, remains unknown. Therefore, Wang et al. performed a series of studies and determined that the expression of HIF1α, HIF2α, and Sox2 was decreased after HBO and that HBO promoted Glioblastoma cell proliferation through cell cycle progression, albeit with a decrease in stemness, thus contributing to chemosensitization via the inhibition of HIF1α/HIF2α-Sox2
((Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, Zhao L, Yan Q, Deng Y, Wu N, Liao B. [[Hyperbaric oxygen]] promotes not only [[glioblastoma]] proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2. Cell Death Discov. 2021 May 13;7(1):103. doi: 10.1038/s41420-021-00486-0. PMID: 33986256.)).