In a study, both [[U118]] cell and [[GSC23]] cell exhibited good printability and [[cell proliferation]]. Compared with 3D-U118, 3D-[[GSC]]23 had a greater ability to form cell [[spheroid]]s, to secrete [[VEGFA]], and to form tubule-like structures in vitro. More importantly, 3D-GSC23 cells had a greater power to transdifferentiate into functional [[endothelial cell]]s, and [[blood vessel]]s composed of [[tumor cell]]s with an abnormal endothelial phenotype was observed in vivo. In summary, 3D bioprinted [[hydrogel]] [[scaffold]] provided a suitable [[tumor microenvironment]] (TME) for glioma cells and GSCs. This bioprinted model supported a novel TME for the research of glioma cells, especially GSCs in glioma vascularization and therapeutic targeting of [[tumor angiogenesis]]
((Wang X, Li X, Ding J, et al. 3D bioprinted glioma microenvironment for glioma vascularization [published online ahead of print, 2020 Aug 10]. J Biomed Mater Res A. 2020;10.1002/jbm.a.37082. doi:10.1002/jbm.a.37082)).