====== Granulomatosis with polyangiitis treatment ======

Untreated, [[Granulomatosis with polyangiitis]] is rapidly fatal, with a median survival of 5 months, and more than 90% of patients are dead within 2 years of diagnosis.

Therapy usually involves 

1. [[steroid]]s

2. immune modulators: includes [[cyclophosphamide]] (Cytoxan®), [[methotrexate]], mofetil (CellCept®)

3. antibodies: [[rituximab]] (Rituxan®) especially for disease relapse. [[Belimumab]] (Benlysta®) is under investigation

4. under investigation: plasma exchange, anti B- & T-cell biologics, and interleukin-5