====== Glycogen Synthase Kinase 3 beta ====== [[Glycogen Synthase Kinase]] 3 beta ([[GSK-3β]]): This is a serine/threonine kinase that negatively regulates the [[β-catenin]] protein. Under normal conditions, GSK-3β is part of a complex with other proteins, like Axin and APC (Adenomatous Polyposis Coli), which are involved in the destruction complex.