====== Glioma spread ======
[[Glioma]]s may spread by the following mechanisms (note: < 10% of recurrent gliomas recur away from the original site):

1. tracking through white matter

a) [[corpus callosum]] (CC)

● through genu or body of CC → bilateral frontal lobe involvement (“butterfly glioma”)

● through splenium of CC → bilateral parietal or occipital lobes

b) cerebral peduncles → midbrain involvement

c) internal capsule → encroachment of basal ganglion tumors into centrum semiovale

d) uncinate fasciculus → simultaneous frontal and temporal lobe tumors

e) interthalamic adhesion → bilateral thalamic gliomas

2. CSF pathways (subarachnoid seeding): 10–25% frequency of meningeal and ventricular seeding
by high grade gliomas

3. rarely, gliomas may spread systemically