=====Gadobenic acid===== Gadobenic acid (tradename MultiHance) is a complex of [[gadolinium]] with the ligand BOPTA. In the form of the diglumine salt it functions as a gadolinium-based MRI contrast medium, under the trade name gadobenate dimeglumine. BOPTA is a derivative of DTPA in which one terminal carboxyl group, –C(O)OH is replaced by -C–O–CH2C6H5. Thus gadobenic acid is closely related to gadopentetic acid. BOPTA itself was first synthesized in 1995. In the "gadobenate" ion gadolinium ion is 9-coordinate with BOPTA acting as an 8-coordinating ligand. The ninth position is occupied by a water molecule, which exchanges rapidly with water molecules in the immediate vicinity of the strongly paramagnetic complex, providing a mechanism for MRI contrast enhancement. 139La NMR studies on the diamagnetic La-BOPTA2- complex suggest that the Gd complex maintains in solution the same kind of coordination as found, by X-ray crystallography, in the solid state for Gd-BOPTA disodium salt. Half the routine contrast agent dose at 7 T provided higher lesion enhancement than the full dose at 3T which indicates the possibility of dose reduction at 7 T ((Noebauer-Huhmann IM, Szomolanyi P, Kronnerwetter C, Widhalm G, Weber M, Nemec S, Juras V, Ladd ME, Prayer D, Trattnig S. Brain tumours at 7T MRI compared to 3T--contrast effect after half and full standard contrast agent dose: initial results. Eur Radiol. 2015 Jan;25(1):106-12. doi: 10.1007/s00330-014-3351-2. Epub 2014 Sep 7. PubMed PMID: 25194707.)).