Fungal spondylodiscitis is often because of Candida albicans or other common Candida species, whereas unusual strains such as Candida sake are often thought to be nonpathogenic. In patients with chronic disorders such as end-stage renal disease (ESRD) spondylodiscitis can also be caused by rare fungal strains that are usually thought to be nonpathogenic; a correct diagnostic workup is essential, as such forms can promptly respond to common antimycotic agents ((Palmisano A, Benecchi M, De Filippo M, Maggiore U, Buzio C, Vaglio A. Candida sake as the causative agent of spondylodiscitis in a hemodialysis patient. Spine J. 2011 Mar;11(3):e12-6. doi: 10.1016/j.spinee.2011.01.026. PubMed PMID: 21377597.))