Fission, in the context of biology and cellular biology, refers to the process of splitting or dividing a single entity into two or more smaller entities. It is commonly used to describe several processes in different biological contexts:

Mitochondrial Fission: This is one of the most well-known examples. Mitochondrial fission is the process by which a single mitochondrion (the energy-producing organelle in cells) divides into two or more smaller mitochondria. This process is regulated by proteins like DNM1L (Dynamin-1-like protein) and is crucial for maintaining mitochondrial health and function.

Cellular Fission: In cell biology, fission can refer to the division of a single cell into two daughter cells. This process occurs during cell division and is essential for growth, tissue repair, and maintaining the number of cells in an organism. There are two types of cellular fission: mitosis and meiosis.

Mitosis: This is a form of cell division that results in two identical daughter cells, each with the same number of chromosomes as the parent cell. It is responsible for growth and tissue repair in multicellular organisms.

Meiosis: This is a specialized form of cell division that occurs in the production of gametes (sperm and egg cells). It results in four non-identical daughter cells, each with half the number of chromosomes as the parent cell. Meiosis is essential for sexual reproduction.

Nuclear Fission: This term is often used in the context of physics and nuclear energy. Nuclear fission is the process by which the nucleus of an atom splits into two or more smaller nuclei, accompanied by the release of a significant amount of energy. It is the basis for nuclear power plants and nuclear weapons.

Bacterial Fission: In microbiology, bacterial fission refers to the process of a bacterial cell dividing into two daughter cells through binary fission. This is how bacteria reproduce and increase their population.

The specific details and mechanisms of fission can vary depending on the context, but the fundamental concept involves the division of an entity into smaller, usually similar, entities.
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There is an urgent need for novel diagnostic and therapeutic strategies for patients with [[Glioblastoma]]. Previous studies have shown that BCL2-like 13 (BCL2L13) is a member of the [[BCL2]] family regulating [[cell growth]] and [[apoptosis]] in different types of [[tumor]]s. However, the clinical significance, biological role, and potential mechanism of GBM remain unexplored. 
In a study, Wang et al. showed that BCL2L13 expression is significantly upregulated in GBM [[cell line]]s and clinical GBM [[tissue]] [[sample]]s. Mechanistically, BCL2L13 targeted [[DNM1L]] at the [[Ser616]] site, leading to mitochondrial [[fission]] and high [[mitophagy]] flux. Functionally, these alterations significantly promoted the [[proliferation]] and [[invasion]] of GBM cells both [[in vitro]] and [[in vivo]]. Overall, these findings demonstrated that BCL2L13 plays a significant role in promoting [[mitophagy]] via DNM1L-mediated mitochondrial fission in GBM. Therefore, the regulation and biological function of BCL2L13 render it a candidate molecular target for [[glioblastoma treatment]]
((Wang J, Chen A, Xue Z, Liu J, He Y, Liu G, Zhao Z, Li W, Zhang Q, Chen A, Wang J, Li X, Wang X, Huang B. BCL2L13 promotes [[mitophagy]] through [[DNM1L]]-mediated mitochondrial [[fission]] in [[glioblastoma]]. Cell Death Dis. 2023 Sep 2;14(9):585. doi: 10.1038/s41419-023-06112-4. PMID: 37660127.)).