Fibronectin is a high-molecular weight (~440kDa) [[glycoprotein]] of the [[extracellular matrix]] that binds to membrane-spanning receptor proteins called [[integrin]]s.

Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
----


[[Alpha-5 beta-1]] (α5β1), also known as the [[fibronectin]] receptor, is an [[integrin]] that binds to matrix macromolecules and proteinases and thereby stimulates [[angiogenesis]].

It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).

α5β1-integrin is transported inside the cell by the kinesin KIF1C, a kinesin-3 organelle transporter that walks along microtubules.