Extragonadal [[germ cell tumor]]s have been documented to arise in midline locations, most commonly in the anterior mediastinum, retroperitoneum, and the [[pineal gland]] or [[suprasellar region]]s of the brain ((van Battum P, Huijberts MS, Heijckmann AC, Wilmink JT, Nieuwenhuijzen Kruseman AC. Intracranial multiple midline germinomas: is histological verification crucial for therapy? Neth J Med. 2007 Nov;65(10):386-9. PubMed PMID: 18057461.)).