===== Engineering Flair ===== **Engineering flair** refers to the creative and technically complex design of synthetic biological systems that emphasize novelty and structure, often without sufficient attention to biological relevance or therapeutic value. ==== Characteristics ==== * Use of modular protein domains, fusion constructs, and multicomponent systems * Prioritization of elegance or innovation over practicality * Lack of disease relevance, clinical scalability, or translational need ==== Critical Usage ==== Often used pejoratively to highlight studies that overengineer a system for academic appeal rather than solving a real problem. ==== Example ==== An extracellular vesicle engineered with five synthetic tags and viral fusion proteins may display engineering flair, but is not inherently meaningful unless it improves therapeutic delivery in a clinically relevant model.