====== Engelbert Knosp ====== In [[1993]] [[Engelbert Knosp]] et al. offered the [[Knosp grade]] system for showing invasion of [[cavernous sinus]] by [[pituitary macroadenoma]]. Briefly, the much laterally adenoma grows and surrounds the [[internal carotid artery]] (ICA), the more grade level is. The grading defined by the relation of carotid lines with the limits of invasion. These lines passes through supra- and [[intracavernous internal carotid artery]] in [[coronal]] view. There are medial, median and lateral carotid lines ((Knosp E, Steiner E, Kitz K, Matula C. pituitary neuroendocrine tumors with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery. 1993 Oct;33(4):610-7; discussion 617-8. PubMed PMID: 8232800. )).