====== Dysembryoplastic neuroepithelial tumor classification ======

Two distinct forms (do not appear to have different prognoses):

Simple form: [[glioneuronal]] elements consisting of axon bundles perpendicular to the cortical surface, lined with oligodendroglial-like cells that are [[S-100]] positive and [[GFAP]] negative. Normal appearing neurons floating in a pale eosinophilic matrix are scattered between these columns (no resemblance to ganglion cells, unlike gangliogliomas).

Complex form: glioneuronal elements as described above in the simple form, with glial nodules scattered throughout. The glial component may mimic a low-grade [[fibrillary astrocytoma]]. Foci of [[cortical dysplasia]] occur
((Adada B, Sayed K. Dysembryoplastic neuroepithelial tumors.Contemp Neurosurg.2004; 26:1–5)).
----
Molecular studies are needed to better understand the biological nature of GNTs and to refine their classification system
((Chen SY, Wang W, Wang LM, Lin QT, Zhao GG, Xu G, Lu DH, Piao YS. Glioneuronal 
tumours with features of rosette-forming glioneuronal tumours of the fourth
ventricle and dysembryoplastic neuroepithelial tumours: a report of three cases. 
Histopathology. 2015 Jun 3. doi: 10.1111/his.12750. [Epub ahead of print] PubMed 
PMID: 26040650.
)).