====== Dysbiosis ======

Dysbiosis is a term used to describe an imbalance in the microbial communities that live in and on the body, particularly the [[gut microbiota]]. It refers to a situation where there is an overgrowth or undergrowth of certain types of microorganisms, which can lead to negative health outcomes. Dysbiosis of the gut [[microbiome]] has been linked to various health conditions such as inflammatory bowel disease, irritable bowel syndrome, obesity, and even neurological disorders like Parkinson's and Alzheimer's disease. The causes of dysbiosis can include dietary factors, antibiotic use, stress, and other environmental factors.
----
The systemic [[inflammation]] response to the [[ischemic stroke]], followed by [[immunosuppression]] in focal [[neurologic deficit]]s and other inflammatory [[damage]], reduces the circulating [[immune cell]] counts and multiorgan infectious [[complication]]s such as intestinal and [[gut]] dysfunction dysbiosis. Evidence showed that [[microbiota]] dysbiosis plays a role in [[neuroinflammation]] and peripheral [[immune response]] after [[stroke]], changing the [[lymphocyte]] populations. Multiple [[immune cell]]s, including lymphocytes, engage in complex and dynamic immune responses in all stages of stroke and may be a pivotal moderator in the bidirectional [[immunomodulation]] between ischemic stroke and gut [[microbiota]]
((Pu B, Zhu H, Wei L, Gu L, Zhang S, Jian Z, Xiong X. The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota. Transl Stroke Res. 2023 May 4. doi: 10.1007/s12975-023-01151-7. Epub ahead of print. PMID: 37140808.)).