====== DNMT ======

DNMTs play several important roles in [[DNA methylation]] and development of cancers. 

see [[DNMT1]].

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Ma et al., from the Zhejiang Sci-Tech University, Hangzhou, Zhejiang, China examined associations between [[DNMT]]s expression and clinicopathological features or promoter [[methylation]] status of [[tumor suppressor gene]]s (TSGs). 

Overexpression of DNMTs was detected in [[pituitary neuroendocrine tumor]]s. Frequencies of [[DNMT1]] [[overexpression]] were significantly higher in [[macroadenoma]]s, invasive tumors, and grade III and IV tumors. [[DNMT3A]] was frequently detected in invasive tumors and grade IV tumors. In addition, DNMT1 and DNMT3A were frequently detected in high-methylation tumors. Furthermore, in [[multivariate logistic regression]], the significant association between DNMT1 or DNMT3A and high-methylation status persisted after adjusting for clinicopathological features. 

The findings suggested that tumor overexpression of DNMT1 and DNMT3A is associated with tumor aggressive behavior and high-methylation status in pituitary neuroendocrine tumors. This data support a possible role of DNMT1 and DNMT3A in TSG promoter methylation leading to pituitary neuroendocrine tumor invasion and suggest that inhibition of DNMTs has the potential to become a new therapeutic approach for [[invasive pituitary neuroendocrine tumor]]
((Ma HS, Wang EL, Xu WF, Yamada S, Yoshimoto K, Qian ZR, Shi L, Liu LL, Li XH.
Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA
(Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior
and Hypermethylation of Tumor Suppressor Genes in Human pituitary neuroendocrine tumors. Med
Sci Monit. 2018 Jul 13;24:4841-4850. doi: 10.12659/MSM.910608. PubMed PMID:
30002361.
)).