====== DNA replication ======

[[DNA]] replication is the biological process of producing two identical replicas of DNA from one original DNA [[molecule]]. This process occurs in all living organisms and is the basis for biological inheritance. The cell possesses the distinctive property of division, which makes replication of DNA essential.
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[[SSBP1]] is essential for mitochondrial [[DNA replication]] and maintenance, with defects leading to a spectrum of disease that includes [[optic atrophy]] and/or [[retinal dystrophy]], occurring with or without extraocular features. A study of Jurkute et al. provided evidence of intrafamilial variability and confirmed the existence of an autosomal recessive inheritance in SSBP1-disease consequent upon a previously unreported genotype
((Jurkute N, D'Esposito F, Robson AG, Pitceathly RDS, Cordeiro F, Raymond FL, Moore AT, Michaelides M, Yu-Wai-Man P, Webster AR, Arno G; Genomics England Research Consortium. SSBP1-Disease Update: Expanding the Genetic and Clinical Spectrum, Reporting Variable Penetrance and Confirming Recessive Inheritance. Invest Ophthalmol Vis Sci. 2021 Dec 1;62(15):12. doi: 10.1167/iovs.62.15.12. PMID: 34905022; PMCID: PMC8684315.)).