Diffuse glioma patients are far from being cured by conventional therapies, and there is an urgent need for other therapeutic approaches
((Reardon DA, Rich JN, Friedman HS, Bigner DD (2006) Recent advances in the treatment of malignant astrocytoma. J Clin Oncol 24:1253–1265)).

The management of diffuse gliomas has undergone many changes since 2000s, with novel approaches to surgery, radiation, and chemotherapy improving survival and quality of life for patients
((Jansen M, Yip S, Louis DN. Molecular pathology in adult gliomas: diagnostic, prognostic and predictive markers. Lancet Neurol 2010;9:717–26)).

With regard to surgery, a more extensive surgical resection has been associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas
((Hardesty DA, Sanai N. The value of glioma extent of resection in the modern neurosurgical era. Front Neurol 2012;3:140–47)).