Diffuse infiltrative gliomas are by far the most common primary brain tumors in adults, esp. its most malignant form, [[glioblastoma multiforme]] (Glioblastoma) ((CBTRUS (2006) CBTRUS statistical report. Primary brain tumors in the United States, 1998–2002. Central Brain Tumor Registry of the United States. http://www.cbtrus.org)). Diffuse gliomas are the second most common [[central nervous system tumor]]s, behind meningiomas, and account for roughly 80% of primary malignant brain tumors ((Bondy ML, Scheurer ME, Malmer B, et al. Brain tumor epidemiology: consensus from the brain tumor epidemiology consortium (BTEC). Cancer 2008;113:1953–68)) ((Jansen M, Yip S, Louis DN. Molecular pathology in adult gliomas: diagnostic, prognostic and predictive markers. Lancet Neurol 2010;9:717–26)) ((Theeler BJ, Yung WK, Fuller GN, et al. Moving toward molecular classification of diffuse gliomas in adults. Neurology 2012;79:1917–26)).