[[Anticholinergic]]s may negatively impact [[cognition]] and [[memory]]
((Moga DC, Carnahan RM, Lund BC, et al. Risks and benefits of bladder antimuscarinics among elderly residents of Veterans Affairs Community Living Centers. J Am Med Dir Assoc. 2013; 14:749–760))
((Kay GG, Ebinger U. Preserving cognitive function for patients with overactive bladder: evidence for a dif- ferential effect with darifenacin. Int J Clin Pract. 2008; 62:1792–1800)).
Newer agents ([[tolterodine]], [[darifenacin]]) have less impact on memory. [[Trospium]], a quaternary amine, crosses the blood-brain barrier less readily than other anticholinergics and may have a less negative impact
((Kay GG, Ebinger U. Preserving cognitive function for patients with overactive bladder: evidence for a dif- ferential effect with darifenacin. Int J Clin Pract. 2008; 62:1792–1800)).