====== Cyclophilin A ======

Cyclophilin A (CypA) is a cytosolic [[protein]] that belongs to the peptidyl-prolyl isomerase (PPIase) family and the major intracellular target of the immunosuppressive drug [[cyclosporin A]] (CsA).

Increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after [[head trauma]], substantializing cyclophilin A as a potential [[biomarker]] for prognostic prediction of [[TBI]]
((Jin HH, Mao TM, Bai ZQ, Chen Y, Ji HL, Jin Y. The 90-day prognostic value of
serum cyclophilin A in traumatic brain injury. Clin Chim Acta. 2018 Jun 6. pii:
S0009-8981(18)30295-X. doi: 10.1016/j.cca.2018.06.009. [Epub ahead of print]
PubMed PMID: 29885319.
)).

Cyclophilin A has been found to be involved in many inflammatory diseases via its receptor, cluster of differentiation 147 ([[CD147]]). 

Cyclophilin A/CD147 interactions may participate in [[subarachnoid hemorrhage]]-induced early [[brain injury]] via increasing neuronal [[apoptosis]] pathway, at least partly through the ERK1/2-nuclear factor-κB pathway. Cyclophilin A/CD147 may be a suitable therapeutic target for subarachnoid hemorrhage
((Dang B, Li H, Xu X, Shen H, Wang Y, Gao A, He W, Wang Z, Chen G. Cyclophilin
A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury
After Subarachnoid Hemorrhage in Rats. Crit Care Med. 2015 Jun 27. [Epub ahead of
print] PubMed PMID: 26132882.
)).

Results provide evidence for the important contribution of CypA as a pertinent component acting through NF-κB-Sox9 in regulation of chondrogenesis signaling. These findings are important to better understand signal-induced chondrogenesis of chondrogenic progenitors in physiological and pathophysiological contexts
((Guo M, Shen J, Kwak JH, Choi B, Lee M, Hu S, Zhang X, Ting K, Soo CB, Chiu RH.
Novel role for cyclophilin a in regulation of chondrogenic commitment and
endochondral ossification. Mol Cell Biol. 2015 Jun 15;35(12):2119-30. doi:
10.1128/MCB.01414-14. Epub 2015 Apr 13. PubMed PMID: 25870110; PubMed Central
PMCID: PMC4438250.
)).