====== Cowden syndrome ======

Cowden [[syndrome]] (also known as Cowden's disease and multiple hamartoma syndrome) is an autosomal dominant inherited condition characterized by benign overgrowths called [[hamartoma]]s as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers.
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The clinical symptoms of Cowden syndrome do not always correlate with the genetic results. However, recent improvements in genetic testing suggest the importance of diagnosing this disease using both clinical and genetic approaches, in collaboration with genetic experts, to ensure an accurate diagnosis and appropriate surveillance for malignant tumors
((Arai H, Akagi K, Nakagawa A, Onai Y, Utsu Y, Masuda S, Aotsuka N. Clinical and genetic diagnosis of Cowden syndrome: A case report of a rare PTEN germline variant and diverse clinical presentation. Medicine (Baltimore). 2023 Jan 6;102(1):e32572. doi: 10.1097/MD.0000000000032572. PMID: 36607858.))
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