====== 🧠 Cortistatin (CORT) ======

A [[neuropeptide]] highly homologous to [[somatostatin]].

Also binds [[somatostatin receptor]]s (SSTRs) but has unique effects, particularly in the [[immune system]] and sleep modulation.

Unlike SST, CORT can bind additional receptors, such as [[ghrelin]] receptors and Mas-related G protein–coupled receptors (MRGPRs).

Plays a role in modulating sleep, neuronal excitability, and inflammation.