====== Clinical study design ======
There is inadequate neurosurgical [[literature]] discussing appropriate [[clinical study]] design. 

Louie et al. explored considerations for 2 fundamental study designs of epidemiology: experimental and observational cohort studies, through examples of theoretical yet realistic neurosurgical research questions. By examining 2 common neurosurgical procedures-namely, subdural drains for evacuation of chronic subdural hematoma, and the utility of navigation for placing external ventricular drains-we characterize the framework of cohort study models for clinical research applications
((Louie CE, D'Agostino E, Woods A, Ryken T. Study Design in Neurosurgical
Research: Considerations for Observational and Experimental Cohort Studies.
Neurosurgery. 2019 Sep 24. pii: nyz386. doi: 10.1093/neuros/nyz386. [Epub ahead
of print] PubMed PMID: 31552423.
)).