====== Cingulate gyrus function ====== For an excellent review of data regarding the complex functional role of the [[cingulate gyrus]] and the surrounding structures of the [[frontal lobe]], see Rushworth et al. ((Rushworth MF, Buckley MJ, Behrens TE, Walton ME, Bannerman DM: Functional organization of the medial frontal cortex. Curr Opin Neurobiol 17:220–227, 2007)). Functionally, the [[cingulate gyrus]] is part of the [[limbic system]] with extensive connectivity to different anatomical and functional areas. Many studies were published concerning the cingulate area and neuropsychological findings ((di Pellegrino G, Ciaramelli E, Ladavas E: The regulation of cognitive control following rostral anterior cingulate cortex lesion in humans. J Cogn Neurosci 19:275–286, 2007)) ((Sumner P, Nachev P, Morris P, Peters AM, Jackson SR, Kennard C, et al: Human medial frontal cortex mediates unconscious inhibition of voluntary action. Neuron 54:697–711, 2007)), functional and diffusion tensor imaging ((Concha L, Gross DW, Beaulieu C: Diffusion tensor tractography of the limbic system. AJNR Am J Neuroradiol 26:2267–2274, 2005)) ((Mohamed IS, Otsubo H, Shroff M, Donner E, Drake J, Snead OC III: Magnetoencephalography and diffusion tensor imaging in gelastic seizures secondary to a cingula)), lesion studies ((Hornak J, Bramham J, Rolls ET, Morris RG, O’Doherty J, Bullock PR, et al: Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain 126:1691–1712, 2003)) ((Nakayama N, Okumura A, Shinoda J, Nakashima T, Iwama T: Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis. J Neurol Neurosurg Psychiatry 77:856–862, 2006)), and electrophysiological stimulation studies with implanted electrodes ((Kawasaki H, Adolphs R, Oya H, Kovach C, Damasio H, Kaufman O, et al: Analysis of single-unit responses to emotional scenes in human ventromedial prefrontal cortex. J Cogn Neurosci 17:1509–1518, 2005)) ((Sperli F, Spinelli L, Pollo C, Seeck M: Contralateral smile and laughter, but no mirth, induced by electrical stimulation of the cingulate cortex. Epilepsia 47:440–443, 2006)) ((Tankus A, Yeshurun Y, Flash T, Fried I: Encoding of speed and direction of movement in the human supplementary motor area. J Neurosurg 110:685–695, 2009)).