====== Christian Migliarese ======

Department of Neurosurgery, [[Massachusetts General Hospital]], [[Boston]], MA, USA.

====== Relevance Analysis of Selected Research Articles ======

1. [[Combination Therapy]] of [[Adagrasib]] and [[Abemaciclib]] in NSCLC Brain [[Metastasis]] (KRAS-G12C, CDKN2A loss)
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  * **Neurosurgery [[relevance]]:** '''High'''. Targets brain metastases; neurosurgeons must consider systemic options that affect surgical decisions.
  * **Oncology relevance:** '''Very high'''. KRAS-G12C is a hot target; combination with CDK4/6 inhibition is cutting-edge.
  * **[[Clinical impact]]:** Personalization of therapy may delay or reduce the need for surgery or radiosurgery.

=== 2. PTEN Potentiation of Oncolytic HSV Therapy for Glioblastoma ===
  * **Neurosurgery relevance:** '''Very high'''. Glioblastoma is a core concern in neurosurgical oncology; virotherapy may be integrated intraoperatively.
  * **Oncology relevance:** '''High'''. Combines gene therapy and immunotherapy approaches in neuro-oncology.
  * **Clinical impact:** Preclinical but promising as adjunct to surgical resection.

=== Summary Table ===
^ Article Title ^ Neurosurgery ^ Oncology ^ Clinical Practice ^
| [[Combination Therapy]] in [[KRAS-G12C]] NSCLC Brain Mets | ★★★★☆ | ★★★★★ | ★★★★☆ |
| [[PTEN]] + [[Oncolytic]] [[HSV]] in [[Glioblastoma]] | ★★★★★ | ★★★★☆ | ★★★☆☆ |