====== China National Knowledge Infrastructure ======


CNKI (China National Knowledge Infrastructure, 中国知网) is a key national information construction project under the lead of Tsinghua University, and supported by PRC Ministry of Education, PRC Ministry of Science, Propaganda Department of the Communist Party of China and PRC General Administration of Press and Publication. This project was firstly launched in 1996 by Tsinghua University and Tsinghua Tongfang Company. The first database was China Academic Journals Full-text Database (CD version), which became popular in China rapidly, especially in academic libraries. In 1999, CNKI started to develop online databases. Till now, CNKI has built a comprehensive China Integrated Knowledge Resources System, including journals, doctoral dissertations, masters' theses, proceedings, newspapers, yearbooks, statistical yearbooks, ebooks, patents, standards and so on.[2] 10 services centers have been set in Beijing, North America, Japan, North Korea, Taiwan and Hong Kong. And it is widely used by universities, research institutes, governments, think tanks, companies, hospitals and public libraries around the world. Also, it contains more and more e-book which is needed by students who needs the professional resources.
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[[CYFRA 21-1]] has been widely studied as an important [[biomarker]] in [[non-small cell lung cancer]] for both [[diagnosis]] and [[prognosis]]. Many studies have also assessed the clinical applications of [[CYFRA 21-1]] in head and neck [[cancer]], but the diagnostic and prognostic values of CYFRA 21-1 are not yet fully established. 

A [[pooled analysis]] aimed to evaluate the diagnostic accuracy and prognostic applications of CYFRA 21-1 in patients with head and neck cancer. A systematic retrieval of [[literature]]s was conducted without time or language restrictions by searching [[PubMed]], [[EMBASE]], [[Web of Science]], [[Cochrane library]] and [[China National Knowledge Infrastructure]]. Twenty studies were eligible for [[systematic review]], of which 14 conformed for diagnostic analysis and 7 for prognostic analysis. The pooled sensitivity and specificity of CYFRA 21-1 analysis were 0.53 (95% CI: 0.39-0.67) and 0.97 (95% CI: 0.93-0.99), respectively. A high level of CYFRA 21-1 was significantly correlated with shorter [[overall survival]] (HR 1.33, 95% CI: 1.13-1.56) and disease-free survival (HR 1.48; 95%CI: 1.10-1.97). Current [[evidence]] indicates that the level of CYFRA 21-1 in the serum could be used as an indicator for monitoring tumor status and evaluating its curative effects
((Liu L, Xie W, Xue P, Wei Z, Liang X, Chen N. Diagnostic accuracy and
prognostic applications of CYFRA 21-1 in head and neck cancer: A systematic
review and meta-analysis. PLoS One. 2019 May 9;14(5):e0216561. doi:
10.1371/journal.pone.0216561. eCollection 2019. PubMed PMID: 31071161.
)).

===== Unclassified =====

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