====== Cerium oxide nanoparticle ======
[[Cerium oxide]] [[nanoparticle]]s have been shown to defend against [[blood brain barrier]] damage in cerebral ischemic brain [[stroke]]. While cerium oxide nanoparticles is highly permeable across the blood-brain barrier and also these [[nanoparticle]]s are effective [[antioxidant]]s, due to its ability to either donate or obtain [[electron]]s with alternative +3 and +4 valence states. This oxidation state of cerium oxide has shown efficiency in neutralizing generated [[free radical]]s in biological systems has been explored action for cerebral ischemic brain stroke. The nanoparticles are encapsulated on the poly-(lactide-co-glycolide)-polyethyleneglycol copolymer matrixes as nanoparticulate delivery vehicles and it can be enhanced brain targeted drug delivery. Furthermore, the results of spectroscopic and microscopic analysis confirmed that peripheral PEG-PLGA co-polymer chains provide excellent reactivity with nanoparticles which might improve the interface bonds of the nanocomposite formation. Mainly, neuroprotective properties of prepared CeO2-PEG/PLGA matrixes with and without nanoparticles are comparatively studied by using transient middle cerebral artery occlusion (MCAO) model of brain stroke. The prepared CeO2 nanoparticles combined with effective PEG/PLGA matrixes exhibited greater efficacy resulted in a lessening of focal ischemia by 60% and 78% decrease in brain edema in comparable to the control animals. The results are demonstrated that the neuroprotective efficiency of CeO2 nanoparticles with PEG/PLGA has enhanced and primarily protected the brain cortex areas from ischemic damage
((Gao Y, Chen X, Liu H. A facile approach for synthesis of nano-CeO(2) particles
loaded co-polymer matrix and their colossal role for blood-brain barrier
permeability in Cerebral Ischemia. J Photochem Photobiol B. 2018 May
3;187:184-189. doi: 10.1016/j.jphotobiol.2018.05.003. [Epub ahead of print]
PubMed PMID: 30173122.)).