====== Cerebral large artery disease ======

Cerebral [[large artery disease]] (CLAD) is defined as stenosis or occlusion of either the [[carotid artery]] or the [[middle cerebral artery]] of 50% or more.

In patients with CLAD, elevated plasma [[VEGF]] might be associated with [[cerebral microbleed]]s (CMBs), especially those located in the cortex and/or at the gray-white junction.

[[Large artery]] atherosclerosis is an important cause of [[ischemic stroke]]. Recent randomized clinical trials have helped clarify the treatment options for conditions such as [[Carotid artery atherosclerotic disease]] and [[intracranial atherosclerosis]].

see [[Carotid artery atherosclerotic disease]].