The severity and the duration of tissue hypoperfusion determine the fate of the ischemic tissue.

[[Neurogenesis]] in the [[cerebral infarction]] after an ischemic event is important to the rehabilitation of patients. 

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[[RBP4]] may be used as a predictive factor of [[diabetic nephropathy]] patients complicated with silent [[cerebral infarction]] (SCI). and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI
((Chen D, Huang X, Lu S, Deng H, Gan H, Du X, Weixue T. RBP4/Lp-PLA2/Netrin-1
signaling regulation of cognitive dysfunction in diabetic nephropathy complicated
with silent cerebral infarction. Exp Clin Endocrinol Diabetes. 2017 Jul 13. doi: 
10.1055/s-0043-109099. [Epub ahead of print] PubMed PMID: 28704853.
)).