====== Cerebral circulation ======

Cerebral [[circulation]] is the movement of [[blood]] through the network of the [[cerebral artery]] and [[cerebral venous system]] supplying the [[brain]]. 

see [[Cerebral blood flow]].

Restoring the circulation is the primary goal in emergency treatment of [[cerebral ischemia]]. 
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[[Microcirculation]] plays a significant role in [[cerebral metabolism]] and [[blood flow control]], yet explaining and predicting functional mechanisms remains elusive because it is difficult to make physiologically accurate mathematical models of the vascular network. As a precursor to the human brain, a paper presented a computational framework for synthesizing anatomically accurate network models for the cortical [[blood supply]] in [[mouse]]. It addresses two critical deficiencies in cerebrovascular modeling. At the microscopic length scale of individual capillaries, Linninger et al., presented a novel synthesis method for building anatomically consistent capillary networks with loops and anastomoses (=microcirculatory closure). This overcomes shortcomings in existing algorithms which are unable to create closed circulatory networks. A second critical innovation allowed the incorporation of detailed anatomical features from image data into vascular growth. Specifically, [[computed tomography]] and two photon laser scanning microscopy data are input into the novel synthesis [[algorithm]] to build the cortical circulation for the entire mouse brain [[in silico]]. Computer predictions of blood flow and oxygen exchange executed on synthetic large-scale network models are expected to elucidate poorly understood functional mechanisms of the [[cerebral circulation]]
((Linninger A, Hartung G, Badr S, Morley R. Mathematical synthesis of the
cortical circulation for the whole mouse brain-part I. theory and image
integration. Comput Biol Med. 2019 May 14;110:265-275. doi:
10.1016/j.compbiomed.2019.05.004. [Epub ahead of print] PubMed PMID: 31247510.
)).