====== Central Hypothyroidism ====== Central [[hypothyroidism]] refers to [[thyroid hormone]] deficiency due to a disorder of the [[pituitary]], [[hypothalamus]], or hypothalamic-pituitary portal circulation, resulting in diminished thyroid-stimulating hormone ([[TSH]]), thyrotropin-releasing hormone ([[TRH]]), or both. [[Aqueductal stenosis]] in adulthood. [[Hypothalamic hamartoma]]s ---- The most frequent cause of central hypothyroidism (CeH) is [[pituitary neuroendocrine tumor]]s, but the mechanisms remain unclear. see [[Central Hypothyroidism in Acromegaly]].