Cellular dysfunction is a commonplace sequel of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction.
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[[Aging]] is accompanied by [[functional loss]] of many cellular [[pathway]]s, creating an increased risk of many [[aging complications]] (ARC). Aging causes [[stem cell exhaustion]] with a concomitant increase in [[cellular dysfunction]].