The [[Cosman-Roberts-Wells]] [[stereotactic]] instrument is a recently developed modification, based on an arc-radius design, of the [[Brown-Roberts-Wells]] [[stereotactic frame]] utilizing the existing fixation and fiducial components of the Brown-Roberts-Wells [[stereotactic]] system to localize and verify [[target]] data. The design modification has been made with a view to facilitating technical approaches both in [[stereotactic biopsy]] and in stereotactic [[craniotomy]], whilst encompassing the same stereotactic space. Initial experience with the Cosman-Roberts-Wells instrument is reported. Over a 5-month period 55 procedures were performed which included 40 stereotactic biopsies, five CT-guided stereotactic craniotomies, three stereotactic placements of a Bennett Ball for [[thalamotomy]], three stereotactic implantations of intracranial [[electrode]]s for recording in [[drug resistant epilepsy]], three aspirations of [[cyst]] or haematoma and one implantation of a Gutin catheter for interstitial brachytherapy. There was minimal morbidity and no mortality related to operation. This frame offers rapid targeting without the need to pre-determine entry points, as well as allowing direct lateral passes and unimpeded stereotactic craniotomy ((Pell MF, Thomas DG. The initial experience with the Cosman-Roberts-Wells stereotactic system. Br J Neurosurg. 1991;5(2):123-8. PubMed PMID: 1863372. )).