====== Bioabsorbable Magnesium Alloy Stent ======

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Advances in [[stent-assisted coiling]] have incrementally expanded [[endovascular treatment]] options for [[complex intracranial aneurysm]]s. After successful [[coil]] consolidation and [[aneurysm]] [[occlusion]], endovascular [[scaffold]]s are no longer needed. Thus, bioresorbable stents that disappear after aneurysm healing could avoid future [[risk]]s of in-stent [[thrombosis]] and the need for lifelong [[antiplatelet therapy]].

To assess the applicability and compatibility of a bioresorbable [[magnesium]]- alloy [[stent]] (brMAS) for assisted [[coiling]].

Saccular sidewall aneurysms were created in 84 male [[Wistar rat]]s and treated with brMAS alone, brMAS + [[aspirin]], or brMAS + coils + aspirin. Control groups included no treatment (natural course), solely aspirin treatment, or conventional [[cobalt]]-[[chromium]] stent + coils + aspirin treatment. After 1 and 4 weeks, aneurysm specimens were harvested and macroscopically, histologically, and molecularly examined for healing, parent artery perfusion status, and inflammatory reactions. Stent degradation was monitored for up to 6 months with micro-computed and optical coherence tomography.

Aneurysms treated with brMAS showed advanced healing, [[neointima]] formation, and subsequent stent degradation. Additional administration of aspirin sustained aneurysm healing while reducing stent-induced intraluminal and periadventitial inflammatory responses. No negative interaction was detected between platinum coils and brMAS. Progressive brMAS degradation was confirmed.

brMAS induced appropriate healing in this sidewall aneurysm model. The concept of using bioresorbable materials to promote complete aneurysm healing and subsequent stent degradation seems promising. These results should encourage further [[device]] refinements and clinical evaluation of this treatment strategy for cerebrovascular [[aneurysm]]s
((Grüter BE, Täschler D, Strange F, Rey J, von Gunten M, Grandgirard D, Leib SL,
Remonda L, Widmer HR, Nevzati E, Fandino J, Marbacher S, Coluccia D. Testing
bioresorbable stent feasibility in a rat aneurysm model. J Neurointerv Surg. 2019
Mar 9. pii: neurintsurg-2018-014697. doi: 10.1136/neurintsurg-2018-014697. [Epub 
ahead of print] PubMed PMID: 30852526.
)).