About a third of soft tissue tumors are recognized by gene fusions. Some of these fusions are not histotype specific and occur in entities with totally different clinicopathological features. A good example is the fusion between EWSR1 and genes of the [[CREB]] transcription factor gene family ([[CREB1]] or [[ATF1]])
((Sciot R, Jacobs S, Calenbergh FV, Demaerel P, Wozniak A, Debiec-Rychter M.
Primary myxoid mesenchymal tumor with intracranial location: report of a case
with a EWSR1-ATF1 fusion. Histopathology. 2017 Nov 15. doi: 10.1111/his.13437.
[Epub ahead of print] PubMed PMID: 29143432.
)).