====== Aspergillus endocarditis ======

A rare [[case]] of native mitral valve AE in a 63-year-old man, with a probable [[COVID-19]]-associated invasive pulmonary [[aspergillosis]] nine months ago treated with antifungals.

In the last admission, the [[lethargy]], neurological deficit, and septic-embolic [[brain abscess]] in brain [[MRI]] led to suspicion of [[infective endocarditis]]. Transesophageal two-dimensional [[echocardiograph]]y and color Doppler flow velocity mapping showed a large highly mobile mass destroying leaflet and severe mitral regurgitation. The Surgical valve replacement is performed. The surgical valve replacement is performed. Direct microscopic examination and [[culture]] of the explanted and vegetative mass revealed Aspergillus section Fumiagati confirmed by molecular method. Despite the administration of [[voriconazole]] and transient improvement the patient expired.

As AE is a late consequence of COVID-19-associated invasive pulmonary aspergillosis, therefore, long-term follow-up of invasive aspergillosis, and prompt diagnosis of surgical and systemic antifungal therapy treatment, are warranted to provide robust management
((Najafi N, Moslemi A, Ghafari R, Shayesteh Azar S, Nabati M, Faeli L, Salimi M, Mirzakhani R, Shokohi T. Post-COVID-19 fatal Aspergillus endocarditis: A case report. J Clin Lab Anal. 2022 Dec 19:e24816. doi: 10.1002/jcla.24816. Epub ahead of print. PMID: 36535906.)).