====== ANKRD22 ======

ANKRD22 (Ankyrin repeat domain-containing protein 22) is a human protein that is encoded by the ANKRD22 gene. It is located on chromosome 17q12 and belongs to the ankyrin repeat-containing protein family.

While the function of ANKRD22 is not well understood, some studies have suggested that it may be involved in the regulation of gene expression and cell differentiation. Additionally, ANKRD22 has been implicated in several disease processes, including cancer and neurodegenerative disorders.

Research on ANKRD22 is ongoing, and more studies are needed to fully understand its role in biological processes and diseases.
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The high expression of ANKRD22 in [[glioma]]s and its correlation with survival were identified based on the [[Cancer Genome Atlas]] database. Similar [[expression]] trends were observed in [[glioma]] [[tissue]]s and [[cell line]]s. Functionally, the loss of ANKRD22 suppressed glioma [[cell proliferation]], [[migration]], and [[invasion]] and [[cell cycle]] [[progression]] [[in vitro]] and tumor [[growth]] in vivo. Mechanistically, ANKRD22 interacted with the [[E2F]] [[transcription factor]] 1 ([[E2F1]]), thereby upregulating maternal embryonic leucine zipper kinase ([[MELK]]) protein expression. Moreover, E2F1 overexpression partly restored ANKRD22 silence-mediated tumor suppressive effects in glioma cells. 
This data highlight the oncogenic [[role]] of ANKRD22 in gliomas via E2F1/MELK signaling, which may serve as a promising target for [[glioma treatment]]
((Liu X, Zhao J, Wu Q, Wang L, Lu W, Feng Y. ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression. J Neuropathol Exp Neurol. 2023 May 10:nlad034. doi: 10.1093/jnen/nlad034. Epub ahead of print. PMID: 37164633.))