====== Androgen receptor ======

Some evidence about the role of the [[androgen]] [[receptor]] (AR) in [[glioblastoma pathogenesis]] has been reported, but no study has focused on measuring the activity of the AR in GB. 

Molecular and clinical data from [[The Cancer Genome Atlas]] [[database]] were used. The AR-expression at the protein level was obtained from reversed-phase protein array (RPPA) assays. The AR activity was determined by calculating the AR-score, an index calculated by using the expression (at RNA level) of 13 androgen-responsive genes. Univariate and multivariate [[Cox regression]] analyses were performed. Finally, a correlation analysis was conducted between protein expression data and the AR score.

Two hundred and thirty-three patients were included. RPPA data showed a mean AR abundance of 0.027(Statistical Deviation = 0.38) in GB. The univariate Cox regression analysis showed that the AR-Score was associated with a worse prognosis (Hazard Ratio (HR) = 1.070) while the AR-expression did not show any relationship with survival (HR = 0.869). The association of the AR-score with worse overall survival (OS) was still significant in the multivariate analysis (HR = 1.054). The highest correlation coefficients between the AR-score and RPPA were identified in a group of proteins involved in apoptotic process regulation.

GB patients with a high AR activity present a worse prognosis in terms of OS. Thus, the activity of the AR may have a pathogenic role in GB. In this regard, the activation of the AR in GB may be associated with a dysregulation of apoptosis
((Fariña-Jerónimo H, de Vera A, Medina L, Plata-Bello J. Androgen Receptor Activity Is Associated with Worse Survival in Glioblastoma. J Integr Neurosci. 2022 Apr 22;21(3):86. doi: 10.31083/j.jin2103086. PMID: 35633167.)).