In [[ALK]]+ [[NSCLC]], the [[ALK]] gene undergoes a rearrangement, called a [[translocation]], within the chromosome to create a fusion between ALK and another gene
((Solomon B, Wilner KD, Shaw AT. Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-Small-cell lung cancer. Clin Pharmacol Ther. 2014;95:15-23. PMID: 24091716)).