====== Acid-suppressive drug ======

There are two classes of [[Acid-suppressive drug]]s:

[[Proton‐pump inhibitor]]s (PPIs), which stop acid secretion by inhibiting proton pumps located in the canalicular membrane of the parietal cell; and histamine‐2 receptor antagonists (H2RAs), which target [[histamine]], one of the primary regulators of [[acid]] secretion.
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[[Acid-suppressive drug]]s were significantly associated with [[all-cause mortality]] in patients with [[nonvalvular atrial fibrillation]] (NVAF)  taking [[oral anticoagulant]]s (OACs)
((Arai H, Ueda S, Uchida K, Sakakibara F, Kinjo N, Nezu M, Morimoto T. Association between Acid-Suppressive [[Drug]]s and [[Clinical Outcome]]s in Patients with [[Nonvalvular Atrial Fibrillation]]. Drugs R D. 2022 Jul 19. doi: 10.1007/s40268-022-00392-5. Epub ahead of print. PMID: 35854203.)).