With 3 [[Tesla]], the [[volumetry]] of [[CA4]]/[[Dentate gyrus]] (DG) was associated with the pathological changes in DG in [[mesial temporal lobe epilepsy]] (MTLE) patients. The volumetry of CA4/DG with preoperative 3T [[MRI]] could predict the [[postoperative seizure]] outcomes in those patients
((Na M, Liu Y, Shi C, Gao W, Ge H, Wang Y, Wang H, Long Y, Shen H, Shi C, Lin Z.
Prognostic value of CA4/DG volumetry with 3T magnetic resonance imaging on
postoperative outcome of epilepsy patients with dentate gyrus pathology. Epilepsy
Res. 2014 Oct;108(8):1315-25. doi: 10.1016/j.eplepsyres.2014.06.005. Epub 2014
Jul 7. PubMed PMID: 25085233.
)).

====Case series====
A retrospective study comprises 26 patients (11 males/15 females, mean age 34±12years, range 13-50 years) with 3 Tesla MRI-negative focal epilepsies who underwent resective epilepsy surgery. Non-invasive and invasive presurgical diagnostic modalities, type and localization of resection, clinical and epileptological outcome with a minimum follow-up of 1year (range 1-11 years, mean 2.5±2.3years) after surgery as well as outcome predictors were evaluated.

All patients underwent invasive video-EEG monitoring after implantation of intracerebral depth and/or subdural electrodes. Ten patients received temporal and 16 extratemporal or multilobar (n=4) resections. There was no perioperative death or permanent morbidity. Overall, 12 of 26 patients (46%) were completely seizure-free (Engel IA) and 65% had a favorable outcome (Engel I-II). In particular, seizure-free ratio was 40% in the temporal and 50% in the extratemporal group. In the temporal group, long duration of epilepsy correlated with poor seizure outcome, whereas congruent unilateral FDG-PET hypometabolism correlated with a favorable outcome.

In almost two thirds of temporal and extratemporal epilepsies defined as "non-lesional" by 3 Tesla MRI criteria, a favorable postoperative seizure outcome (Engel I-II) can be achieved with accurate multimodal presurgical evaluation including intracranial EEG recordings. In the temporal group, most favorable results were obtained when FDG-PET displayed congruent unilateral hypometabolism
((Kogias E, Klingler JH, Urbach H, Scheiwe C, Schmeiser B, Doostkam S, Zentner
J, Altenmüller DM. 3 Tesla MRI-negative focal epilepsies: Presurgical evaluation,
postoperative outcome and predictive factors. Clin Neurol Neurosurg. 2017 Oct
31;163:116-120. doi: 10.1016/j.clineuro.2017.10.038. [Epub ahead of print] PubMed
PMID: 29101859.
)).