====== 1983 ====== [[1982]]-[[1984]]. From a [[retrospective]] [[study]] of 412 [[thoracolumbar injury]], [[Francis Denis]] introduced the concept of [[middle column]] or middle osteoligamentous complex between the traditionally recognized posterior [[ligament]]ous complex and the [[anterior longitudinal ligament]] ((Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976). [[1983]] Nov-Dec;8(8):817-31. PubMed PMID: 6670016. )). ---- [[Percutaneous balloon compression trigeminal rhizotomy]], has been used to treat [[trigeminal neuralgia]] since [[1983]]. ---- In [[1983]], as crystal-based neodymium-doped yttrium aluminum garnet Nd:YAG laser was introduced for tissue ablation, and some studies followed of laser ablation for [[brain tumor]]s (( S.G. Bown, Phototherapy in tumors, World Journal of Surgery, 7 (1983) 700-709.)) ((K. Sugiyama, T. Sakai, I. Fujishima, H. Ryu, K. Uemura, T. Yokoyama, Stereotactic interstitial laser-hyperthermia using Nd-YAG laser, Stereotactic and functional neurosurgery, 54-55 (1990) 501-505.)) ((M. Bettag, F. Ulrich, R. Schober, G. Furst, K.J. Langen, M. Sabel, J.C. Kiwit, Stereotactic laser therapy in cerebral gliomas, Acta neurochirurgica. Supplementum, 52 (1991) 81-83.)) ((F.X. Roux, L. Merienne, B. Leriche, S. Lucerna, B. Turak, B. Devaux, J.P. Chodkiewicz, Laser interstitial thermotherapy in stereotactical neurosurgery, Lasers in Medical Science, 7 (1992) 121-126.)). ---- The [[polymerase]] chain reaction (PCR) is a technology in molecular biology used to amplify a single copy or a few copies of a piece of [[DNA]] across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence. Developed in [[1983]] by Kary Mullis, PCR is now a common and often indispensable technique used in medical and biological research labs for a variety of applications. These include DNA cloning for sequencing, DNA-based phylogeny, or functional analysis of [[gene]]s; the diagnosis of hereditary diseases; the identification of genetic fingerprints (used in forensic sciences and DNA paternity testing); and the detection and diagnosis of infectious diseases. In 1993, Mullis was awarded the Nobel Prize in Chemistry along with Michael Smith for his work on PCR. ---- Introduced in [[1983]], [[Cotrel Dubousset Instrumentation]] is a treatment approach to [[scoliosis]]. Unlike [[Harrington rod]]s, this treatment is more than just an osteodistraction mechanism and allows correction of some of the features of scoliosis untreatable by Harrington rods, such as rib hump.