====== 1664 ====== [[1663]]-[[1665]] ---- In [[1664]], Thomas Willis first postulated that [[cerebrospinal fluid production]] came from the [[choroid plexus]]es and that the fluid was contained within the [[ventricle]]s ((Rengachary SS, Ellenbogen RG: Principles of Neurosurgery, ed 2. Edinburgh: Elsevier Mosby, 2005))